Population Pharmacokinetics of Imipenem in Critically Ill Patients: A Parametric and Nonparametric Model Converge on CKD-EPI Estimated Glomerular Filtration Rate as an Impactful Covariate

BACKGROUND: Population pharmacokinetic (popPK) models for antibiotics are used to improve dosing strategies and individualize dosing by therapeutic drug monitoring. Little is known about the differences in results of parametric versus nonparametric popPK models and their potential consequences in cl...

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Detalles Bibliográficos
Autores principales: de Velde, Femke, de Winter, Brenda C. M., Neely, Michael N., Yamada, Walter M., Koch, Birgit C. P., Harbarth, Stephan, von Dach, Elodie, van Gelder, Teun, Huttner, Angela, Mouton, Johan W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329758/
https://www.ncbi.nlm.nih.gov/pubmed/31956969
http://dx.doi.org/10.1007/s40262-020-00859-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329758/
https://www.ncbi.nlm.nih.gov/pubmed/31956969
http://dx.doi.org/10.1007/s40262-020-00859-1

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