Synthesis of the Thomsen-Friedenreich-antigen (TF-antigen) and binding of Galectin-3 to TF-antigen presenting neo-glycoproteins

The Thomsen-Friedenreich-antigen, Gal(β1–3)GalNAc(α1-O-Ser/Thr (TF-antigen), is presented on the surface of most human cancer cell types. Its interaction with galectin 1 and galectin 3 leads to tumor cell aggregation and promotes cancer metastasis and T-cell apoptosis in epithelial tissue. To furthe...

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Detalles Bibliográficos
Autores principales: Hoffmann, Marius, Hayes, Marc R., Pietruszka, Jörg, Elling, Lothar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329766/
https://www.ncbi.nlm.nih.gov/pubmed/32367478
http://dx.doi.org/10.1007/s10719-020-09926-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329766/
https://www.ncbi.nlm.nih.gov/pubmed/32367478
http://dx.doi.org/10.1007/s10719-020-09926-y

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