Integration of Placental Transfer in a Fetal–Maternal Physiologically Based Pharmacokinetic Model to Characterize Acetaminophen Exposure and Metabolic Clearance in the Fetus

BACKGROUND AND OBJECTIVE: Although acetaminophen is frequently used during pregnancy, little is known about fetal acetaminophen pharmacokinetics. Acetaminophen safety evaluation has typically focused on hepatotoxicity, while other events (fetal ductal closure/constriction) are also relevant. We aime...

Descripción completa

Detalles Bibliográficos
Autores principales: Mian, Paola, Allegaert, Karel, Conings, Sigrid, Annaert, Pieter, Tibboel, Dick, Pfister, Marc, van Calsteren, Kristel, van den Anker, John N., Dallmann, André
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329787/
https://www.ncbi.nlm.nih.gov/pubmed/32052378
http://dx.doi.org/10.1007/s40262-020-00861-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329787/
https://www.ncbi.nlm.nih.gov/pubmed/32052378
http://dx.doi.org/10.1007/s40262-020-00861-7

Ejemplares similares