Global analysis of protein degradation in prion infected cells

Prion diseases are rare, neurological disorders caused by the misfolding of the cellular prion protein (PrP(C)) into cytotoxic fibrils (PrP(Sc)). Intracellular PrP(Sc) aggregates primarily accumulate within late endosomes and lysosomes, organelles that participate in the degradation and turnover of...

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Detalles Bibliográficos
Autores principales: Hutti, Charles R., Welle, Kevin A., Hryhorenko, Jennifer R., Ghaemmaghami, Sina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329860/
https://www.ncbi.nlm.nih.gov/pubmed/32612191
http://dx.doi.org/10.1038/s41598-020-67505-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329860/
https://www.ncbi.nlm.nih.gov/pubmed/32612191
http://dx.doi.org/10.1038/s41598-020-67505-5

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