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Global analysis of protein degradation in prion infected cells
Prion diseases are rare, neurological disorders caused by the misfolding of the cellular prion protein (PrP(C)) into cytotoxic fibrils (PrP(Sc)). Intracellular PrP(Sc) aggregates primarily accumulate within late endosomes and lysosomes, organelles that participate in the degradation and turnover of...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329860/ https://www.ncbi.nlm.nih.gov/pubmed/32612191 http://dx.doi.org/10.1038/s41598-020-67505-5 |