Mesenchymal subtype neuroblastomas are addicted to TGF-βR2/HMGCR-driven protein geranylgeranylation

The identification of targeted agents with high therapeutic index is a major challenge for cancer drug discovery. We found that screening chemical libraries across neuroblastoma (NBL) tumor subtypes for selectively-lethal compounds revealed metabolic dependencies that defined each subtype. Bioactive...

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Detalles Bibliográficos
Autores principales: Stokes, Michael E., Small, Jonnell Candice, Vasciaveo, Alessandro, Shimada, Kenichi, Hirschhorn, Tal, Califano, Andrea, Stockwell, Brent R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329873/
https://www.ncbi.nlm.nih.gov/pubmed/32612149
http://dx.doi.org/10.1038/s41598-020-67310-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329873/
https://www.ncbi.nlm.nih.gov/pubmed/32612149
http://dx.doi.org/10.1038/s41598-020-67310-0

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