Development of AAV Variants with Human Hepatocyte Tropism and Neutralizing Antibody Escape Capacity

Adeno-associated virus (AAV) vectors have been successfully used in patients with bleeding disorders and blindness. For human liver targeting, two major factors restrict effective AAV transduction after systemic administration of AAV vectors: human hepatocyte tropism and neutralizing antibodies (Nab...

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Detalles Bibliográficos
Autores principales: Pei, Xiaolei, Shao, Wenwei, Xing, Allene, Askew, Charles, Chen, Xiaojing, Cui, Caibin, Abajas, Yasmina L., Gerber, David A., Merricks, Elizabeth P., Nichols, Timothy C., Li, Wuping, Samulski, R. Jude, Li, Chengwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329936/
https://www.ncbi.nlm.nih.gov/pubmed/32637455
http://dx.doi.org/10.1016/j.omtm.2020.06.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329936/
https://www.ncbi.nlm.nih.gov/pubmed/32637455
http://dx.doi.org/10.1016/j.omtm.2020.06.003

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