Cargando…
Development of AAV Variants with Human Hepatocyte Tropism and Neutralizing Antibody Escape Capacity
Adeno-associated virus (AAV) vectors have been successfully used in patients with bleeding disorders and blindness. For human liver targeting, two major factors restrict effective AAV transduction after systemic administration of AAV vectors: human hepatocyte tropism and neutralizing antibodies (Nab...
Autores principales: | Pei, Xiaolei, Shao, Wenwei, Xing, Allene, Askew, Charles, Chen, Xiaojing, Cui, Caibin, Abajas, Yasmina L., Gerber, David A., Merricks, Elizabeth P., Nichols, Timothy C., Li, Wuping, Samulski, R. Jude, Li, Chengwen |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Gene & Cell Therapy
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329936/ https://www.ncbi.nlm.nih.gov/pubmed/32637455 http://dx.doi.org/10.1016/j.omtm.2020.06.003 |
Ejemplares similares
-
Superior human hepatocyte transduction with Adeno-associated Virus Vector Serotype 7
por: Shao, Wenwei, et al.
Publicado: (2019) -
Chimeric Mice Engrafted With Canine Hepatocytes Exhibits Similar AAV Transduction Efficiency to Hemophilia B Dog
por: Shao, Wenwei, et al.
Publicado: (2022) -
An Observational Study from Long-Term AAV Re-administration in Two Hemophilia Dogs
por: Sun, Junjiang, et al.
Publicado: (2018) -
AAV Recombineering with Single Strand Oligonucleotides
por: Hirsch, Matthew L., et al.
Publicado: (2009) -
Global CNS Gene Delivery and Evasion of Anti-AAV Neutralizing Antibodies by Intrathecal AAV Administration in Non-Human Primates
por: Gray, Steven J., et al.
Publicado: (2013)