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Reduced replication origin licensing selectively kills KRAS-mutant colorectal cancer cells via mitotic catastrophe
To unravel vulnerabilities of KRAS-mutant CRC cells, a shRNA-based screen specifically inhibiting MAPK pathway components and targets was performed in CaCo2 cells harboring conditional oncogenic KRAS(G12V). The custom-designed shRNA library comprised 121 selected genes, which were previously identif...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330027/ https://www.ncbi.nlm.nih.gov/pubmed/32612138 http://dx.doi.org/10.1038/s41419-020-2704-9 |