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Flexible experimental designs for valid single-cell RNA-sequencing experiments allowing batch effects correction

Despite their widespread applications, single-cell RNA-sequencing (scRNA-seq) experiments are still plagued by batch effects and dropout events. Although the completely randomized experimental design has frequently been advocated to control for batch effects, it is rarely implemented in real applica...

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Detalles Bibliográficos
Autores principales: Song, Fangda, Chan, Ga Ming Angus, Wei, Yingying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330047/
https://www.ncbi.nlm.nih.gov/pubmed/32612268
http://dx.doi.org/10.1038/s41467-020-16905-2