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Straightforward Generation of Ultrapure Off-the-Shelf Allogeneic CAR-T Cells
Here, we developed a straightforward methodology to generate TCRαβ negative (allogeneic) cells for CAR-T cell therapies. With an early and transient expression of an anti-CD3 CAR in the engineered donor T cells, we programmed these cells to self-eliminate the TCR+ cell population and obtained an ult...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330105/ https://www.ncbi.nlm.nih.gov/pubmed/32671047 http://dx.doi.org/10.3389/fbioe.2020.00678 |