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Straightforward Generation of Ultrapure Off-the-Shelf Allogeneic CAR-T Cells

Here, we developed a straightforward methodology to generate TCRαβ negative (allogeneic) cells for CAR-T cell therapies. With an early and transient expression of an anti-CD3 CAR in the engineered donor T cells, we programmed these cells to self-eliminate the TCR+ cell population and obtained an ult...

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Detalles Bibliográficos
Autores principales:	Juillerat, Alexandre, Tkach, Diane, Yang, Ming, Boyne, Alex, Valton, Julien, Poirot, Laurent, Duchateau, Philippe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Bioengineering and Biotechnology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330105/ https://www.ncbi.nlm.nih.gov/pubmed/32671047 http://dx.doi.org/10.3389/fbioe.2020.00678

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