Dual Inhibition of MAPK and JAK2/STAT3 Pathways Is Critical for the Treatment of BRAF Mutant Melanoma

BRAF and MEK inhibitors significantly prolong progression-free survival in patients with BRAF mutant melanoma. However, most patients quickly develop drug resistance. The mechanism of drug resistance is complicated and remains to be further explored. Here, we found that inhibition of the MAPK pathwa...

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Detalles Bibliográficos
Autores principales: Zhao, Kun, Lu, Yanrong, Chen, Younan, Cheng, Jingqiu, Zhang, Wengeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330142/
https://www.ncbi.nlm.nih.gov/pubmed/32637584
http://dx.doi.org/10.1016/j.omto.2020.06.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330142/
https://www.ncbi.nlm.nih.gov/pubmed/32637584
http://dx.doi.org/10.1016/j.omto.2020.06.004

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