Excess Rab4 rescues synaptic and behavioral dysfunction caused by defective HTT-Rab4 axonal transport in Huntington’s disease

Huntington’s disease (HD) is characterized by protein inclusions and loss of striatal neurons which result from expanded CAG repeats in the poly-glutamine (polyQ) region of the huntingtin (HTT) gene. Both polyQ expansion and loss of HTT have been shown to cause axonal transport defects. While studie...

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Detalles Bibliográficos
Autores principales: White, Joseph A., Krzystek, Thomas J., Hoffmar-Glennon, Hayley, Thant, Claire, Zimmerman, Katherine, Iacobucci, Gary, Vail, Julia, Thurston, Layne, Rahman, Saad, Gunawardena, Shermali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331280/
https://www.ncbi.nlm.nih.gov/pubmed/32611447
http://dx.doi.org/10.1186/s40478-020-00964-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331280/
https://www.ncbi.nlm.nih.gov/pubmed/32611447
http://dx.doi.org/10.1186/s40478-020-00964-z

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