Excess Rab4 rescues synaptic and behavioral dysfunction caused by defective HTT-Rab4 axonal transport in Huntington’s disease

Huntington’s disease (HD) is characterized by protein inclusions and loss of striatal neurons which result from expanded CAG repeats in the poly-glutamine (polyQ) region of the huntingtin (HTT) gene. Both polyQ expansion and loss of HTT have been shown to cause axonal transport defects. While studie...

Descripción completa

Detalles Bibliográficos
Autores principales: White, Joseph A., Krzystek, Thomas J., Hoffmar-Glennon, Hayley, Thant, Claire, Zimmerman, Katherine, Iacobucci, Gary, Vail, Julia, Thurston, Layne, Rahman, Saad, Gunawardena, Shermali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331280/
https://www.ncbi.nlm.nih.gov/pubmed/32611447
http://dx.doi.org/10.1186/s40478-020-00964-z

Ejemplares similares

Ejemplares similares