Enhanced Notch3 signaling contributes to pulmonary emphysema in a Murine Model of Marfan syndrome

Marfan syndrome (MFS) is a heritable disorder of connective tissue, caused by mutations in the fibrillin-1 gene. Pulmonary functional abnormalities, such as emphysema and restrictive lung diseases, are frequently observed in patients with MFS. However, the pathogenesis and molecular mechanism of pul...

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Detalles Bibliográficos
Autores principales: Jespersen, Kathryn, Liu, Zhibo, Li, Chenxin, Harding, Paul, Sestak, Kylie, Batra, Rishi, Stephenson, Christopher A., Foley, Ryan T., Greene, Harrison, Meisinger, Trevor, Baxter, B. Timothy, Xiong, Wanfen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331498/
https://www.ncbi.nlm.nih.gov/pubmed/32616814
http://dx.doi.org/10.1038/s41598-020-67941-3

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