Tofacitinib treatment aggravates Staphylococcus aureus septic arthritis, but attenuates sepsis and enterotoxin induced shock in mice

Tofacitinib, a janus kinase inhibitor, is a novel immunosuppressive drug for treatment of rheumatoid arthritis (RA). Septic arthritis (SA) and sepsis caused by Staphylococcus aureus (S. aureus), for which RA patients are at risk, are infections with high mortality. The aim of this study was to inves...

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Detalles Bibliográficos
Autores principales: Jarneborn, Anders, Mohammad, Majd, Engdahl, Cecilia, Hu, Zhicheng, Na, Manli, Ali, Abukar, Jin, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331611/
https://www.ncbi.nlm.nih.gov/pubmed/32616791
http://dx.doi.org/10.1038/s41598-020-67928-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331611/
https://www.ncbi.nlm.nih.gov/pubmed/32616791
http://dx.doi.org/10.1038/s41598-020-67928-0

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