ULK1 and ULK2 are less redundant than previously thought: computational analysis uncovers distinct regulation and functions of these autophagy induction proteins

Macroautophagy, the degradation of cytoplasmic content by lysosomal fusion, is an evolutionary conserved process promoting homeostasis and intracellular defence. Macroautophagy is initiated primarily by a complex containing ULK1 or ULK2 (two paralogs of the yeast Atg1 protein). To understand the dif...

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Detalles Bibliográficos
Autores principales: Demeter, Amanda, Romero-Mulero, Mari Carmen, Csabai, Luca, Ölbei, Márton, Sudhakar, Padhmanand, Haerty, Wilfried, Korcsmáros, Tamás
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331686/
https://www.ncbi.nlm.nih.gov/pubmed/32616830
http://dx.doi.org/10.1038/s41598-020-67780-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331686/
https://www.ncbi.nlm.nih.gov/pubmed/32616830
http://dx.doi.org/10.1038/s41598-020-67780-2

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