Tetanus insensitive VAMP2 differentially restores synaptic and dense core vesicle fusion in tetanus neurotoxin treated neurons

The SNARE proteins involved in the secretion of neuromodulators from dense core vesicles (DCVs) in mammalian neurons are still poorly characterized. Here we use tetanus neurotoxin (TeNT) light chain, which cleaves VAMP1, 2 and 3, to study DCV fusion in hippocampal neurons and compare the effects on...

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Detalles Bibliográficos
Autores principales: Hoogstraaten, Rein I., van Keimpema, Linda, Toonen, Ruud F., Verhage, Matthijs
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331729/
https://www.ncbi.nlm.nih.gov/pubmed/32616842
http://dx.doi.org/10.1038/s41598-020-67988-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331729/
https://www.ncbi.nlm.nih.gov/pubmed/32616842
http://dx.doi.org/10.1038/s41598-020-67988-2

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