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A systems-biology approach to molecular machines: Exploration of alternative transporter mechanisms
Motivated by growing evidence for pathway heterogeneity and alternative functions of molecular machines, we demonstrate a computational approach for investigating two questions: (1) Are there multiple mechanisms (state-space pathways) by which a machine can perform a given function, such as cotransp...
Autores principales: | George, August, Bisignano, Paola, Rosenberg, John M., Grabe, Michael, Zuckerman, Daniel M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331975/ https://www.ncbi.nlm.nih.gov/pubmed/32614821 http://dx.doi.org/10.1371/journal.pcbi.1007884 |
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