Thyroid hormone receptor beta mutations alter photoreceptor development and function in Danio rerio (zebrafish)

We investigate mutations in trβ2, a splice variant of thrb, identifying changes in function, structure, and behavior in larval and adult zebrafish retinas. Two N-terminus CRISPR mutants were identified. The first is a 6BP+1 insertion deletion frameshift resulting in a truncated protein. The second i...

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Detalles Bibliográficos
Autores principales: Deveau, Ciana, Jiao, Xiaodong, Suzuki, Sachihiro C., Krishnakumar, Asha, Yoshimatsu, Takeshi, Hejtmancik, J Fielding, Nelson, Ralph F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332105/
https://www.ncbi.nlm.nih.gov/pubmed/32569302
http://dx.doi.org/10.1371/journal.pgen.1008869

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332105/
https://www.ncbi.nlm.nih.gov/pubmed/32569302
http://dx.doi.org/10.1371/journal.pgen.1008869

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