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The association between mercury concentrations and lipid profiles in the Korean National Environmental Health Survey (KoNEHS) cycle 3

BACKGROUND: High concentrations of mercury intake from seafood are known to cause various side effects in humans, including on the nervous system. Various studies have reported the effects of mercury concentrations in humans; however, the association between dyslipidemia, a cardiovascular disease ri...

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Autores principales: Sohn, Soo Ho, Heo, Han Cheol, Jo, Seongmin, Park, Chulyong, Sakong, Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Occupational & Environmental Medicine 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332352/
https://www.ncbi.nlm.nih.gov/pubmed/32676197
http://dx.doi.org/10.35371/aoem.2020.32.e19
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author Sohn, Soo Ho
Heo, Han Cheol
Jo, Seongmin
Park, Chulyong
Sakong, Joon
author_facet Sohn, Soo Ho
Heo, Han Cheol
Jo, Seongmin
Park, Chulyong
Sakong, Joon
author_sort Sohn, Soo Ho
collection PubMed
description BACKGROUND: High concentrations of mercury intake from seafood are known to cause various side effects in humans, including on the nervous system. Various studies have reported the effects of mercury concentrations in humans; however, the association between dyslipidemia, a cardiovascular disease risk factor, and mercury remains controversial. Therefore, this study aimed to investigate the association between mercury accumulation and cholesterol concentrations in a Korean population. METHODS: We analyzed data of a sample of 3,228 respondents obtained from the Korean National Environmental Health Survey cycle 3, surveyed between 2015 and 2017, to determine how lipid profiles changed according to the blood mercury concentrations (BHg) and urine mercury concentrations (UHg). Multiple regression analysis was used to determine the effects of mercury concentrations among various factors affecting blood cholesterol levels. RESULTS: The arithmetic mean (AM) of BHg was 2.91 (2.81–3.02) μg/L, and the geometric mean (GM) was 2.71 (2.59–2.85) μg/L. The AM of UHg was 0.52 (0.48–0.56) μg/L, and the GM was 0.35 (0.33–0.38) μg/L. Lipid profiles were more related to the BHg than to the UHg. Total cholesterol (total-C), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels increased significantly as BHg increased in males, and total-C, triglyceride, and LDL-C levels increased significantly in females. Multiple regression analysis indicated that BHg were significantly associated with total-C, HDL-C, and LDL-C levels. CONCLUSIONS: We found an association between mercury exposure and the risk of dyslipidemia; however, further studies are required to elucidate a causal association.
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spelling pubmed-73323522020-07-15 The association between mercury concentrations and lipid profiles in the Korean National Environmental Health Survey (KoNEHS) cycle 3 Sohn, Soo Ho Heo, Han Cheol Jo, Seongmin Park, Chulyong Sakong, Joon Ann Occup Environ Med Research Article BACKGROUND: High concentrations of mercury intake from seafood are known to cause various side effects in humans, including on the nervous system. Various studies have reported the effects of mercury concentrations in humans; however, the association between dyslipidemia, a cardiovascular disease risk factor, and mercury remains controversial. Therefore, this study aimed to investigate the association between mercury accumulation and cholesterol concentrations in a Korean population. METHODS: We analyzed data of a sample of 3,228 respondents obtained from the Korean National Environmental Health Survey cycle 3, surveyed between 2015 and 2017, to determine how lipid profiles changed according to the blood mercury concentrations (BHg) and urine mercury concentrations (UHg). Multiple regression analysis was used to determine the effects of mercury concentrations among various factors affecting blood cholesterol levels. RESULTS: The arithmetic mean (AM) of BHg was 2.91 (2.81–3.02) μg/L, and the geometric mean (GM) was 2.71 (2.59–2.85) μg/L. The AM of UHg was 0.52 (0.48–0.56) μg/L, and the GM was 0.35 (0.33–0.38) μg/L. Lipid profiles were more related to the BHg than to the UHg. Total cholesterol (total-C), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels increased significantly as BHg increased in males, and total-C, triglyceride, and LDL-C levels increased significantly in females. Multiple regression analysis indicated that BHg were significantly associated with total-C, HDL-C, and LDL-C levels. CONCLUSIONS: We found an association between mercury exposure and the risk of dyslipidemia; however, further studies are required to elucidate a causal association. Korean Society of Occupational & Environmental Medicine 2020-06-22 /pmc/articles/PMC7332352/ /pubmed/32676197 http://dx.doi.org/10.35371/aoem.2020.32.e19 Text en Copyright © 2020 Korean Society of Occupational & Environmental Medicine https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Sohn, Soo Ho
Heo, Han Cheol
Jo, Seongmin
Park, Chulyong
Sakong, Joon
The association between mercury concentrations and lipid profiles in the Korean National Environmental Health Survey (KoNEHS) cycle 3
title The association between mercury concentrations and lipid profiles in the Korean National Environmental Health Survey (KoNEHS) cycle 3
title_full The association between mercury concentrations and lipid profiles in the Korean National Environmental Health Survey (KoNEHS) cycle 3
title_fullStr The association between mercury concentrations and lipid profiles in the Korean National Environmental Health Survey (KoNEHS) cycle 3
title_full_unstemmed The association between mercury concentrations and lipid profiles in the Korean National Environmental Health Survey (KoNEHS) cycle 3
title_short The association between mercury concentrations and lipid profiles in the Korean National Environmental Health Survey (KoNEHS) cycle 3
title_sort association between mercury concentrations and lipid profiles in the korean national environmental health survey (konehs) cycle 3
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332352/
https://www.ncbi.nlm.nih.gov/pubmed/32676197
http://dx.doi.org/10.35371/aoem.2020.32.e19
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