Integrating untargeted metabolomics, genetically informed causal inference, and pathway enrichment to define the obesity metabolome

BACKGROUND: Obesity and its associated diseases are major health problems characterized by extensive metabolic disturbances. Understanding the causal connections between these phenotypes and variation in metabolite levels can uncover relevant biology and inform novel intervention strategies. Recent...

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Detalles Bibliográficos
Autores principales: Hsu, Yu-Han H., Astley, Christina M., Cole, Joanne B., Vedantam, Sailaja, Mercader, Josep M., Metspalu, Andres, Fischer, Krista, Fortney, Kristen, Morgen, Eric K., Gonzalez, Clicerio, Gonzalez, Maria E., Esko, Tonu, Hirschhorn, Joel N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332400/
https://www.ncbi.nlm.nih.gov/pubmed/32467615
http://dx.doi.org/10.1038/s41366-020-0603-x