Cargando…
Human-IgG-Neutralizing Monoclonal Antibodies Block the SARS-CoV-2 Infection
Coronavirus disease 2019 (COVID-19) has become a worldwide threat to humans, and neutralizing antibodies have therapeutic potential. We have purified more than 1,000 memory B cells specific to SARS-CoV-2 S1 or its RBD (receptor binding domain) and obtain 729 paired heavy- and light-chain fragments....
Autores principales: | Wan, Jinkai, Xing, Shenghui, Ding, Longfei, Wang, Yongheng, Gu, Chenjian, Wu, Yanling, Rong, Bowen, Li, Cheng, Wang, Siqing, Chen, Kun, He, Chenxi, Zhu, Dandan, Yuan, Songhua, Qiu, Chengli, Zhao, Chen, Nie, Lei, Gao, Zhangzhao, Jiao, Jingyu, Zhang, Xiaoyan, Wang, Xiangxi, Ying, Tianlei, Wang, Haibin, Xie, Youhua, Lu, Yanan, Xu, Jianqing, Lan, Fei |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Author(s).
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332464/ https://www.ncbi.nlm.nih.gov/pubmed/32668215 http://dx.doi.org/10.1016/j.celrep.2020.107918 |
Ejemplares similares
-
RBD-Fc-based COVID-19 vaccine candidate induces highly potent SARS-CoV-2 neutralizing antibody response
por: Liu, Zezhong, et al.
Publicado: (2020) -
Identification of Human Single-Domain Antibodies against SARS-CoV-2
por: Wu, Yanling, et al.
Publicado: (2020) -
Characterization and engineering of broadly reactive monoclonal antibody against hepatitis B virus X protein that blocks its interaction with DDB1
por: Tao, Shuai, et al.
Publicado: (2019) -
Potent germline-like monoclonal antibodies: rapid identification of promising candidates for antibody-based antiviral therapy
por: Zhu, Xiaoyi, et al.
Publicado: (2021) -
Engineered Soluble Monomeric IgG1 Fc with Significantly Decreased Non-Specific Binding
por: Wang, Chunyu, et al.
Publicado: (2017)