Histoepigenetic analysis of the mesothelin network within pancreatic ductal adenocarcinoma cells reveals regulation of retinoic acid receptor gamma and AKT by mesothelin

To enable computational analysis of regulatory networks within the cancer cell in its natural tumor microenvironment, we develop a two-stage histoepigenetic analysis method. The first stage involves iterative computational deconvolution to estimate sample-specific cancer-cell intrinsic expression of...

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Detalles Bibliográficos
Autores principales: Lurie, Eugene, Liu, Dongliang, LaPlante, Emily L., Thistlethwaite, Lillian R., Yao, Qizhi, Milosavljevic, Aleksandar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332500/
https://www.ncbi.nlm.nih.gov/pubmed/32616712
http://dx.doi.org/10.1038/s41389-020-00245-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332500/
https://www.ncbi.nlm.nih.gov/pubmed/32616712
http://dx.doi.org/10.1038/s41389-020-00245-3

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