Synthesis of a New Phenyl Chlormethine-Quinazoline Derivative, a Potential Anti-Cancer Agent, Induced Apoptosis in Hepatocellular Carcinoma Through Mediating Sirt1/Caspase 3 Signaling Pathway

Quinazoline derivatives display multiple pharmacological activities and target various biological receptors. Based on the skeleton of quinazoline core, we designed and synthesized three new quinazoline-phenyl chlormethine conjugates (I–III) bearing a Schiff base (C = N) linker, and investigated thei...

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Detalles Bibliográficos
Autores principales: Lv, Jia-jia, Song, Wen-ting, Li, Xin-min, Gao, Jian-mei, Yuan, Ze-li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332554/
https://www.ncbi.nlm.nih.gov/pubmed/32670058
http://dx.doi.org/10.3389/fphar.2020.00911

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332554/
https://www.ncbi.nlm.nih.gov/pubmed/32670058
http://dx.doi.org/10.3389/fphar.2020.00911

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