Design and synthesis of selective sphingosine-1-phosphate receptor 1 agonists with increased phosphorylation rates

FTY720 and IMMH002, prodrugs for sphingosine-1-phosphate receptor 1 (S1P(1)) agonists, show inadequate and inconsistent levels of phosphorylation in humans compared to that in rats. In this study, FTY720 or IMMH002 analogues (21–24) were designed and synthesized with modified head pieces to improve...

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Detalles Bibliográficos
Autores principales: Xiao, Qiong, Hu, Minwan, Chen, Si, Tang, Yifan, Shi, Zeyu, Jin, Jing, Hu, Jinping, Xie, Ping, Yin, Dali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Short communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332640/
https://www.ncbi.nlm.nih.gov/pubmed/32642418
http://dx.doi.org/10.1016/j.apsb.2019.11.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332640/
https://www.ncbi.nlm.nih.gov/pubmed/32642418
http://dx.doi.org/10.1016/j.apsb.2019.11.005

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