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Design and synthesis of selective sphingosine-1-phosphate receptor 1 agonists with increased phosphorylation rates
FTY720 and IMMH002, prodrugs for sphingosine-1-phosphate receptor 1 (S1P(1)) agonists, show inadequate and inconsistent levels of phosphorylation in humans compared to that in rats. In this study, FTY720 or IMMH002 analogues (21–24) were designed and synthesized with modified head pieces to improve...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332640/ https://www.ncbi.nlm.nih.gov/pubmed/32642418 http://dx.doi.org/10.1016/j.apsb.2019.11.005 |