Metabolic and inflammatory functions of short-chain fatty acid receptors

FFA2 and FFA3 are receptors for short-chain fatty acids which are produced in prodigious amounts by fermentation of poorly digested carbohydrates by gut bacteria. Understanding the roles of these receptors in regulating enteroendocrine, metabolic and immune functions has developed with the productio...

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Detalles Bibliográficos
Autores principales: Bolognini, Daniele, Dedeo, Domonkos, Milligan, Graeme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd 2021
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332907/
https://www.ncbi.nlm.nih.gov/pubmed/32835130
http://dx.doi.org/10.1016/j.coemr.2020.06.005
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author Bolognini, Daniele
Dedeo, Domonkos
Milligan, Graeme
author_facet Bolognini, Daniele
Dedeo, Domonkos
Milligan, Graeme
author_sort Bolognini, Daniele
collection PubMed
description FFA2 and FFA3 are receptors for short-chain fatty acids which are produced in prodigious amounts by fermentation of poorly digested carbohydrates by gut bacteria. Understanding the roles of these receptors in regulating enteroendocrine, metabolic and immune functions has developed with the production and use of novel pharmacological tools and animal models. A complex (patho)physiological scenario is now emerging in which strategic expression of FFA2 and FFA3 in key cell types and selective modulation of their signalling might regulate body weight management, energy homoeostasis and inflammatory disorders.
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spelling pubmed-73329072020-07-06 Metabolic and inflammatory functions of short-chain fatty acid receptors Bolognini, Daniele Dedeo, Domonkos Milligan, Graeme Curr Opin Endocr Metab Res Reviews FFA2 and FFA3 are receptors for short-chain fatty acids which are produced in prodigious amounts by fermentation of poorly digested carbohydrates by gut bacteria. Understanding the roles of these receptors in regulating enteroendocrine, metabolic and immune functions has developed with the production and use of novel pharmacological tools and animal models. A complex (patho)physiological scenario is now emerging in which strategic expression of FFA2 and FFA3 in key cell types and selective modulation of their signalling might regulate body weight management, energy homoeostasis and inflammatory disorders. Elsevier Ltd 2021-02 /pmc/articles/PMC7332907/ /pubmed/32835130 http://dx.doi.org/10.1016/j.coemr.2020.06.005 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Reviews
Bolognini, Daniele
Dedeo, Domonkos
Milligan, Graeme
Metabolic and inflammatory functions of short-chain fatty acid receptors
title Metabolic and inflammatory functions of short-chain fatty acid receptors
title_full Metabolic and inflammatory functions of short-chain fatty acid receptors
title_fullStr Metabolic and inflammatory functions of short-chain fatty acid receptors
title_full_unstemmed Metabolic and inflammatory functions of short-chain fatty acid receptors
title_short Metabolic and inflammatory functions of short-chain fatty acid receptors
title_sort metabolic and inflammatory functions of short-chain fatty acid receptors
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332907/
https://www.ncbi.nlm.nih.gov/pubmed/32835130
http://dx.doi.org/10.1016/j.coemr.2020.06.005
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