Hexokinase 2 displacement from mitochondria‐associated membranes prompts Ca(2+)‐dependent death of cancer cells

Cancer cells undergo changes in metabolic and survival pathways that increase their malignancy. Isoform 2 of the glycolytic enzyme hexokinase (HK2) enhances both glucose metabolism and resistance to death stimuli in many neoplastic cell types. Here, we observe that HK2 locates at mitochondria‐endopl...

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Detalles Bibliográficos
Autores principales: Ciscato, Francesco, Filadi, Riccardo, Masgras, Ionica, Pizzi, Marco, Marin, Oriano, Damiano, Nunzio, Pizzo, Paola, Gori, Alessandro, Frezzato, Federica, Chiara, Federica, Trentin, Livio, Bernardi, Paolo, Rasola, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332982/
https://www.ncbi.nlm.nih.gov/pubmed/32383545
http://dx.doi.org/10.15252/embr.201949117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332982/
https://www.ncbi.nlm.nih.gov/pubmed/32383545
http://dx.doi.org/10.15252/embr.201949117

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