Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy

Autophagy is an essential cellular quality control process that has emerged as a critical one for vascular homeostasis. Here, we show that trichoplein (TCHP) links autophagy with endothelial cell (EC) function. TCHP localizes to centriolar satellites, where it binds and stabilizes PCM1. Loss of TCHP...

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Detalles Bibliográficos
Autores principales: Martello, Andrea, Lauriola, Angela, Mellis, David, Parish, Elisa, Dawson, John C, Imrie, Lisa, Vidmar, Martina, Gammoh, Noor, Mitić, Tijana, Brittan, Mairi, Mills, Nicholas L, Carragher, Neil O, D'Arca, Domenico, Caporali, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332983/
https://www.ncbi.nlm.nih.gov/pubmed/32337819
http://dx.doi.org/10.15252/embr.201948192

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332983/
https://www.ncbi.nlm.nih.gov/pubmed/32337819
http://dx.doi.org/10.15252/embr.201948192

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