Pyruvate anaplerosis is a mechanism of resistance to pharmacological glutaminase inhibition in triple-receptor negative breast cancer

BACKGROUND: Glutamine serves as an important nutrient with many cancer types displaying glutamine dependence. Following cellular uptake glutamine is converted to glutamate in a reaction catalysed by mitochondrial glutaminase. This glutamate has many uses, including acting as an anaplerotic substrate...

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Detalles Bibliográficos
Autores principales: Singleton, Dean C., Dechaume, Anne-Lise, Murray, Pamela M., Katt, William P., Baguley, Bruce C., Leung, Euphemia Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333265/
https://www.ncbi.nlm.nih.gov/pubmed/32450839
http://dx.doi.org/10.1186/s12885-020-06885-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333265/
https://www.ncbi.nlm.nih.gov/pubmed/32450839
http://dx.doi.org/10.1186/s12885-020-06885-3

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