An Integrated Spatial Dynamics—Pharmacokinetic Model Explaining Poor Penetration of Anti-retroviral Drugs in Lymph Nodes

Although combined anti-retroviral therapy (cART) suppresses plasma HIV viremia below the limit of detection in a majority of HIV patients, evidence is emerging that the distribution of the anti-retroviral drugs is heterogeneous in tissue. Clinical studies measuring antiretroviral drug concentrations...

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Detalles Bibliográficos
Autores principales: Jagarapu, Aditya, Piovoso, Michael J., Zurakowski, Ryan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333380/
https://www.ncbi.nlm.nih.gov/pubmed/32676500
http://dx.doi.org/10.3389/fbioe.2020.00667

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333380/
https://www.ncbi.nlm.nih.gov/pubmed/32676500
http://dx.doi.org/10.3389/fbioe.2020.00667

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