Drug Repositioning for Noonan and LEOPARD Syndromes by Integrating Transcriptomics With a Structure-Based Approach

Noonan and LEOPARD syndromes (NS and LS) belong to a group of related disorders called RASopathies characterized by abnormalities of multiple organs and systems including hypertrophic cardiomyopathy and dysmorphic facial features. There are no approved drugs for these two rare diseases, but it is kn...

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Detalles Bibliográficos
Autores principales: Zhu, Liyuan, Roberts, Ruth, Huang, Ruili, Zhao, Jinghua, Xia, Menghang, Delavan, Brian, Mikailov, Mike, Tong, Weida, Liu, Zhichao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333460/
https://www.ncbi.nlm.nih.gov/pubmed/32676024
http://dx.doi.org/10.3389/fphar.2020.00927

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333460/
https://www.ncbi.nlm.nih.gov/pubmed/32676024
http://dx.doi.org/10.3389/fphar.2020.00927

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