Assays and technologies for developing proteolysis targeting chimera degraders

Targeted protein degradation by small-molecule degraders represents an emerging mode of action in drug discovery. Proteolysis targeting chimeras (PROTACs) are small molecules that can recruit an E3 ligase and a protein of interest (POI) into proximity, leading to induced ubiquitination and degradati...

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Detalles Bibliográficos
Autores principales: Liu, Xingui, Zhang, Xuan, Lv, Dongwen, Yuan, Yaxia, Zheng, Guangrong, Zhou, Daohong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Newlands Press Ltd 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333641/
https://www.ncbi.nlm.nih.gov/pubmed/32431173
http://dx.doi.org/10.4155/fmc-2020-0073

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333641/
https://www.ncbi.nlm.nih.gov/pubmed/32431173
http://dx.doi.org/10.4155/fmc-2020-0073

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