Identification and Quantification of Novel Major Metabolites of the Steroidal Aromatase Inhibitor, Exemestane

Exemestane (EXE) is an aromatase inhibitor used for the prevention and treatment of estrogen receptor–positive breast cancer. Although the known major metabolic pathway for EXE is reduction to form the active 17β-dihydro-EXE (17β-DHE) and subsequent glucuronidation to 17β-hydroxy-EXE-17-O-β-D-glucur...

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Detalles Bibliográficos
Autores principales: Luo, Shaman, Chen, Gang, Truica, Cristina I., Baird, Cynthia C., Xia, Zuping, Lazarus, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333658/
https://www.ncbi.nlm.nih.gov/pubmed/30257855
http://dx.doi.org/10.1124/dmd.118.081166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333658/
https://www.ncbi.nlm.nih.gov/pubmed/30257855
http://dx.doi.org/10.1124/dmd.118.081166

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