Immunogenicity of Immunotoxins Containing Pseudomonas Exotoxin A: Causes, Consequences, and Mitigation

Immunotoxins are cytolytic fusion proteins developed for cancer therapy, composed of an antibody fragment that binds to a cancer cell and a protein toxin fragment that kills the cell. Pseudomonas exotoxin A (PE) is a potent toxin that is used for the killing moiety in many immunotoxins. Moxetumomab...

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Detalles Bibliográficos
Autores principales: Mazor, Ronit, Pastan, Ira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333791/
https://www.ncbi.nlm.nih.gov/pubmed/32695104
http://dx.doi.org/10.3389/fimmu.2020.01261

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333791/
https://www.ncbi.nlm.nih.gov/pubmed/32695104
http://dx.doi.org/10.3389/fimmu.2020.01261

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