Disruption of TFIIH activities generates a stress gene expression response and reveals possible new targets against cancer

Disruption of the enzymatic activities of the transcription factor TFIIH by the small molecules Triptolide (TPL) or THZ1 could be used against cancer. Here, we used the MCF10A-ErSrc oncogenesis model to compare the effect of TFIIH inhibitors between transformed cells and their progenitors. We report...

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Detalles Bibliográficos
Autores principales: Uriostegui-Arcos, Maritere, Aguayo-Ortiz, Rodrigo, Valencia-Morales, María del Pilar, Melchy-Pérez, Erika, Rosenstein, Yvonne, Dominguez, Laura, Zurita, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333893/
https://www.ncbi.nlm.nih.gov/pubmed/32543350
http://dx.doi.org/10.1098/rsob.200050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333893/
https://www.ncbi.nlm.nih.gov/pubmed/32543350
http://dx.doi.org/10.1098/rsob.200050

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