Select amino acids in DGCR8 are essential for the UGU-pri-miRNA interaction and processing

Microprocessor, composed of DROSHA and DGCR8, processes primary microRNAs (pri-miRNAs) in miRNA biogenesis. Its cleavage efficiency and accuracy are enhanced because DGCR8 interacts with the apical UGU motif of pri-miRNAs. However, the mechanism and influence of DGCR8–UGU interaction on cellular miR...

Descripción completa

Detalles Bibliográficos
Autores principales: Dang, Thi Lieu, Le, Cong Truc, Le, Minh Ngoc, Nguyen, Trung Duc, Nguyen, Thuy Linh, Bao, Sheng, Li, Shaohua, Nguyen, Tuan Anh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334207/
https://www.ncbi.nlm.nih.gov/pubmed/32620823
http://dx.doi.org/10.1038/s42003-020-1071-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334207/
https://www.ncbi.nlm.nih.gov/pubmed/32620823
http://dx.doi.org/10.1038/s42003-020-1071-5

Ejemplares similares