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Structure of a DNA polymerase abortive complex with the 8OG:dA base pair at the primer terminus
Adenine frequently pairs with the Hoogsteen edge of an oxidized guanine base (8OG) causing G to T transversions. The (syn)8OG:dA base pair is indistinguishable from the cognant base pair and can be extended by DNA polymerases with reduced efficiency. To examine the structural basis of this reduced e...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334213/ https://www.ncbi.nlm.nih.gov/pubmed/32620932 http://dx.doi.org/10.1038/s42003-020-1080-4 |