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The RNA quality control pathway nonsense-mediated mRNA decay targets cellular and viral RNAs to restrict KSHV

Nonsense-mediated mRNA decay (NMD) is an evolutionarily conserved RNA decay mechanism that has emerged as a potent cell-intrinsic restriction mechanism of retroviruses and positive-strand RNA viruses. However, whether NMD is capable of restricting DNA viruses is not known. The DNA virus Kaposi’s sar...

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Detalles Bibliográficos
Autores principales: Zhao, Yang, Ye, Xiang, Shehata, Myriam, Dunker, William, Xie, Zhihang, Karijolich, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334219/
https://www.ncbi.nlm.nih.gov/pubmed/32620802
http://dx.doi.org/10.1038/s41467-020-17151-2