Creation of a High-Yield AAV Vector Production Platform in Suspension Cells Using a Design-of-Experiment Approach

Recombinant adeno-associated virus (rAAV) vectors are a leading gene delivery platform, but vector manufacturing remains a challenge. New methods are needed to increase rAAV yields and reduce costs. Past efforts to improve rAAV production have focused on optimizing a single variable at a time, but t...

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Detalles Bibliográficos
Autores principales: Zhao, Huiren, Lee, Ki-Jeong, Daris, Mark, Lin, Yun, Wolfe, Thomas, Sheng, Jackie, Plewa, Cherylene, Wang, Songli, Meisen, W. Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334306/
https://www.ncbi.nlm.nih.gov/pubmed/32671134
http://dx.doi.org/10.1016/j.omtm.2020.06.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334306/
https://www.ncbi.nlm.nih.gov/pubmed/32671134
http://dx.doi.org/10.1016/j.omtm.2020.06.004

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