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Long-term association of a transcription factor with its chromatin binding site can stabilize gene expression and cell fate commitment

Some lineage-determining transcription factors are overwhelmingly important in directing embryonic cells to a particular differentiation pathway, such as Ascl1 for nerve. They also have an exceptionally strong ability to force cells to change from an unrelated pathway to one preferred by their actio...

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Detalles Bibliográficos
Autores principales: Gurdon, J. B., Javed, Khayam, Vodnala, Munender, Garrett, Nigel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334453/
https://www.ncbi.nlm.nih.gov/pubmed/32532919
http://dx.doi.org/10.1073/pnas.2000467117