Exploring the structural basis of conformational heterogeneity and autoinhibition of human cGMP-specific protein kinase Iα through computational modelling and molecular dynamics simulations

Protein kinase Iα (PKGIα) is a pivotal cyclic guanosine monophosphate (cGMP) signalling protein. Major steps related to the structural plasticity of PKGIα have been inferred but the structural aspects of the auto-inhibition and multidomain tertiary organization of human PKGIα in active and inactive...

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Detalles Bibliográficos
Autores principales: Maryam, Arooma, Khalid, Rana Rehan, Vedithi, Sundeep Chaitanya, ECE, Abdulilah, Çınaroğlu, Suleyman Selim, Siddiqi, Abdul Rauf, Blundell, Tom L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334484/
https://www.ncbi.nlm.nih.gov/pubmed/32670503
http://dx.doi.org/10.1016/j.csbj.2020.06.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334484/
https://www.ncbi.nlm.nih.gov/pubmed/32670503
http://dx.doi.org/10.1016/j.csbj.2020.06.016

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