Identification of unique and shared mitochondrial DNA mutations in neurodegeneration and cancer by single-cell mitochondrial DNA structural variation sequencing (MitoSV-seq)

BACKGROUND: Point mutations and structural variations (SVs) in mitochondrial DNA (mtDNA) contribute to many neurodegenerative diseases. Technical limitations and heteroplasmy, however, have impeded their identification, preventing these changes from being examined in neurons in healthy and disease s...

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Detalles Bibliográficos
Autores principales: Jaberi, Elham, Tresse, Emilie, Grønbæk, Kirsten, Weischenfeldt, Joachim, Issazadeh-Navikas, Shohreh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334819/
https://www.ncbi.nlm.nih.gov/pubmed/32629384
http://dx.doi.org/10.1016/j.ebiom.2020.102868

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334819/
https://www.ncbi.nlm.nih.gov/pubmed/32629384
http://dx.doi.org/10.1016/j.ebiom.2020.102868

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