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Polyamine blockade and binding energetics in the MthK potassium channel
Polyamines such as spermidine and spermine are found in nearly all cells, at concentrations ranging up to 0.5 mM. These cations are endogenous regulators of cellular K(+) efflux, binding tightly in the pores of inwardly rectifying K(+) (K(ir)) channels in a voltage-dependent manner. Although the vol...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Rockefeller University Press
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335011/ https://www.ncbi.nlm.nih.gov/pubmed/32342093 http://dx.doi.org/10.1085/jgp.201912527 |