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Lower Ca(2+) enhances the K(+)-induced force depression in normal and HyperKPP mouse muscles
Hyperkalemic periodic paralysis (HyperKPP) manifests as stiffness or subclinical myotonic discharges before or during periods of episodic muscle weakness or paralysis. Ingestion of Ca(2+) alleviates HyperKPP symptoms, but the mechanism is unknown because lowering extracellular [Ca(2+)] ([Ca(2+)](e))...
Autores principales: | Uwera, Francine, Ammar, Tarek, McRae, Callum, Hayward, Lawrence J., Renaud, Jean-Marc |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335014/ https://www.ncbi.nlm.nih.gov/pubmed/32291438 http://dx.doi.org/10.1085/jgp.201912511 |
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