A yeast platform for high-level synthesis of tetrahydroisoquinoline alkaloids

The tetrahydroisoquinoline (THIQ) moiety is a privileged substructure of many bioactive natural products and semi-synthetic analogs. Plants manufacture more than 3,000 THIQ alkaloids, including the opioids morphine and codeine. While microbial species have been engineered to synthesize a few compoun...

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Detalles Bibliográficos
Autores principales: Pyne, Michael E., Kevvai, Kaspar, Grewal, Parbir S., Narcross, Lauren, Choi, Brian, Bourgeois, Leanne, Dueber, John E., Martin, Vincent J. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335070/
https://www.ncbi.nlm.nih.gov/pubmed/32620756
http://dx.doi.org/10.1038/s41467-020-17172-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335070/
https://www.ncbi.nlm.nih.gov/pubmed/32620756
http://dx.doi.org/10.1038/s41467-020-17172-x

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