Cargando…
A yeast platform for high-level synthesis of tetrahydroisoquinoline alkaloids
The tetrahydroisoquinoline (THIQ) moiety is a privileged substructure of many bioactive natural products and semi-synthetic analogs. Plants manufacture more than 3,000 THIQ alkaloids, including the opioids morphine and codeine. While microbial species have been engineered to synthesize a few compoun...
Autores principales: | Pyne, Michael E., Kevvai, Kaspar, Grewal, Parbir S., Narcross, Lauren, Choi, Brian, Bourgeois, Leanne, Dueber, John E., Martin, Vincent J. J. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335070/ https://www.ncbi.nlm.nih.gov/pubmed/32620756 http://dx.doi.org/10.1038/s41467-020-17172-x |
Ejemplares similares
-
Screening non-conventional yeasts for acid tolerance and engineering Pichia occidentalis for production of muconic acid
por: Pyne, Michael E., et al.
Publicado: (2023) -
Synthesis of Morphinan Alkaloids in Saccharomyces cerevisiae
por: Fossati, Elena, et al.
Publicado: (2015) -
Recent Advances
in the Total Synthesis of the Tetrahydroisoquinoline
Alkaloids (2002–2020)
por: Kim, Alexia N., et al.
Publicado: (2023) -
Genome sequencing of 15 acid-tolerant yeasts
por: Bagley, James A., et al.
Publicado: (2023) -
Biosynthesis of plant tetrahydroisoquinoline alkaloids through an imine reductase route
por: Yang, Lu, et al.
Publicado: (2019)