Persistent telomere cohesion protects aged cells from premature senescence

Human telomeres are bound by the telomere repeat binding proteins TRF1 and TRF2. Telomere shortening in human cells leads to a DNA damage response that signals replicative senescence. While insufficient loading of TRF2 at shortened telomeres contributes to the DNA damage response in senescence, the...

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Detalles Bibliográficos
Autores principales: Azarm, Kameron, Bhardwaj, Amit, Kim, Eugenie, Smith, Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335080/
https://www.ncbi.nlm.nih.gov/pubmed/32620872
http://dx.doi.org/10.1038/s41467-020-17133-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335080/
https://www.ncbi.nlm.nih.gov/pubmed/32620872
http://dx.doi.org/10.1038/s41467-020-17133-4

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